Looking for a natural alternative to Botox? Meet the latest regenerative cosmetic treatment: Rejuran. Also known as “PDRN therapy” or “salmon DNA for your skin” (yes, really — but keep reading), Rejuran is the science-backed, glow-boosting regenerative skin therapy that has taken the aesthetics world (and TikTok, of course) by storm. Think of it as a revitalizing reboot for your skin’s natural ability to heal, hydrate, and look effortlessly flawless.
Originally developed in South Korea and now embraced by elite dermatologists and medspa professionals, Rejuran has been used in injectable form overseas for years. While injectables are not currently FDA-cleared for use in the U.S., Rejuran is gaining popularity stateside in its serum form — most often paired with microneedling or laser treatments for visibly radiant results. Rejuran is the secret weapon you’ll want to know about, so keep reading to learn all about this revolutionary facial treatment that everyone’s talking about.
What Is Rejuran?
What sets it apart from your average collagen booster or hydrating facial? The secret lies in its star ingredient: polynucleotides (PN) derived from an unlikely but highly effective source — salmon DNA.
The Rejuran serum penetrates the skin barrier and targets various concerns, including fine lines, uneven texture, acne scars, pigmentation, and even inflammation, all while enhancing elasticity and skin hydration. Translation? Skin that’s bouncier, smoother, and more radiant with every session.
This naturally-derived skin regeneration treatment is also used to boost post-procedure recovery to get that “glass skin” finish and to help calm a variety of skin concerns.
What Is PDRN (Polydeoxyribonucleotide)?
The main ingredient in Rejuran treatment is PDRN (Polydeoxyribonucleotide). This skin-renewing ingredient consists of small DNA fragments from salmon that are highly biocompatible with human skin. PDRN signals your skin to wake up and get to work — boosting cell turnover, repairing microdamage, and improving elasticity and texture over time.
Sources and Safety of Salmon-Derived Ingredients
Another reason why medical professionals and aestheticians love PDRN is that it’s a naturally-derived ingredient from the DNA of salmon, 97% compatible with human DNA, minimizing the risk of allergic reactions. The salmon are sourced from sustainable fisheries and the extraction process is minimally invasive from using by-products that would have otherwise gone to waste.
Clinical studies have also confirmed its safety and efficacy for cosmetic and medical use.
Why Everyone’s Obsessed With Rejuran
This popular skincare treatment has been used by stars like Kim Kardashian and Jennifer Aniston to improve skin texture and skin elasticity. This skin-boosting treatment helps with a myriad of skin conditions, making it a popular global skincare trend.
Cellular Renewal and Skin Repair
By delivering polynucleotides (PN) directly into the dermis (the middle layer of skin), skin cells receive the signal to regenerate and repair themselves. This process stimulates fibroblasts, the cells responsible for collagen and elastin production.
It’s a perfect option for those dealing with acne scars, enlarged pores, or years of sun damage.
Anti-Aging and Brightening Effects
Rejuran doesn’t freeze muscles or plump like fillers; it works on a deeper level to fight the visible signs of aging. This encourages new collagen growth and helps repair UV damage to soften fine lines, firm sagging skin, even out your skin tone, and help light reflect more evenly across the surface. Rejuran gives you that radiant, glowing skin.
Deep Hydration from Within
Unlike topical moisturizers or treatments, the salmon sperm facial strengthens the skin barrier and promotes better hydration from the inside out, making it an excellent choice for dry or sensitive skin types. The polynucleotides help restore the skin’s natural ability to retain moisture, increasing hyaluronic acid levels.
After a series of treatments, many patients report visibly smoother, dewy skin that feels softer, looks clearer, and radiates healthy luminosity.
Ideal Candidates for Rejuran
You may be wondering: Is this treatment for me? This treatment isn’t just for those chasing trends; it’s for anyone looking to improve their skin’s overall health, strength, and radiance from the inside out.
Rejuran is especially ideal for individuals with mature, dry, or environmentally damaged skin. It’s also a popular choice for women in their 30s and beyond who want more than a quick fix — they’re after long-term skin quality improvements without looking like they’ve had work done.
Can It Be Used on Sensitive Skin?
Yes, and that’s one of the many reasons Rejuran is winning over those with more delicate complexions.
Rejuran is exceptionally gentle and biocompatible, making it suitable for most skin types, including sensitive or reactive skin. The polynucleotides used in the treatment not only promote healing and regeneration but also have strong anti-inflammatory properties. That means less irritation, reduced redness, and a calmer complexion overall.
Rejuran is often recommended for patients struggling with rosacea, post-laser skin sensitivity, or inflammation from over-treated skin. This restorative approach helps soothe while strengthening the skin barrier, leading to a more balanced, resilient, and radiant complexion over time.
What To Expect During and After the Treatment
This treatment may raise some questions (and eyebrows), so here’s a step-by-step guide to walk through the process so you know what to expect before, during, and after. Don’t worry; this isn’t a “grin and bear it” procedure. In fact, many patients describe it as surprisingly comfortable and well worth the glow-up.
The Step-by-Step Rejuran Treatment Guide
Before the treatment can begin, you’ll want to contact one of our highly skilled injectors. Here, you’ll discuss your skin concerns, medical history, and the pros and cons of the treatment for your unique skin.
- Once approved, you’ll arrive at the office without makeup and get your skin thoroughly cleansed to remove oil, makeup, or dirt.
- A topical numbing cream may be applied to minimize discomfort during the treatment.
- A microneedling device creates controlled microchannels across the skin.
- Rejuran serum is applied topically so it can penetrate the skin through the microchannels.
- A soothing serum or cooling mask may follow to calm the skin.
The entire treatment takes less than one hour, and many patients describe the process as comfortable and rewarding.
Downtime and Aftercare Tips
After the Rejuran treatment is over, follow your medical professional’s instructions. Fortunately, Rejuran requires minimal downtime, and you can go right back to work or your daily activities.
Here’s what to expect after your session:
- Mild redness or swelling that usually subsides within 24–72 hours.
- Avoid makeup or harsh skincare products for at least 24 hours to allow your skin time to breathe and heal.
- Steer clear of sun exposure, saunas, and intense workouts post-treatment for a day or two.
As your skin repairs itself naturally, you’ll start to see enhanced elasticity, glow, smoothness, and hydration over the following weeks.
How Often Should You Get Rejuran Treatments?
How often you come in for a treatment will depend on your personal skincare goals, so it’s best to speak with one of our board-certified PNs, NPs, or RNs. In general, most patients begin with 3 to 4 sessions spaced about four weeks apart.
After your initial course, maintenance sessions every 4 to 6 months will help preserve that dewy glow and youthful appearance and strengthen the skin barrier over time.
Can Rejuran Be Used With Other Treatments?
Absolutely! And in fact, Rejuran often shines brightest when paired with complementary treatments. It plays well with others, making it a popular addition to combination therapy plans.
Because of its regenerative and anti-inflammatory properties, Rejuran can enhance the overall results of:
- Laser treatments: Helps calm inflammation and speeds up skin recovery.
- RF or Microneedling treatments: Enhances collagen production and skin repair.
- Botox or dermal fillers: Rejuran focuses on skin quality and health, while the fillers address structure and expression lines, giving you a full facial treatment.
- Hydrafacials or chemical peels: Rejuran helps fortify and nourish the skin after exfoliation treatments.
Of course, any combination approach should be planned with your skincare professional to ensure timing, technique, and product layering are optimized for your skin’s needs.
Reveal Healthier, Younger-Looking Skin With Rejuran
If you’re ready to go beyond surface-level fixes and give your skin the cellular-level rejuvenation it truly deserves, Rejuran could be your next obsession. Discover why this cutting-edge skincare technology is a highly-prized South Korean skin rejuvenation technique taking the skincare world by storm.
Ready to meet your most refreshed and revitalized self? Book a consultation today and let us help you create a personalized plan to revolutionize your skin health and confidence.